General InformationThe best treatment for prevention of another stroke or TIA in patients with narrowing of one of the arteries in the brain is uncertain. A common treatment is the use of anti-clotting medications to prevent blood clots from forming in the narrowed vessel. There are a variety of medicines used for this purpose, including aspirin and clopidogrel (plavix). These medications are usually taken for the rest of a patient's life.
However, a treatment that has been used successfully together with anti-clotting medications in patients with narrowing of the blood vessels of the heart is now being studied in the blood vessels of the brain. This treatment is called stenting.
Recent research has also indicated a benefit in prevention of recurring stroke by Intensive Medical Therapy, which is defined as treating risk factors for stroke like high blood pressure and elevated LDL (low density lipids â the âbadâ form of cholesterol). This is done by:
- keeping the blood level of LDL (low density lipids) under 70
- keeping the systolic blood pressure under 140 (or 130 if you are diabetic)
- if diabetic, keeping the hemoglobin A1c blood level under 7Ã¢ÂÂ°
- if smoker, quitting smoking
- 30-45 minutes of moderate intensity activity 3-5 days a week (walking, jogging, cycling or other aerobic activity)
- weight control that will be measured by a calculation called a BMI (body mass index). This calculation is done by factoring your height and weight together in a formula. The goal is to have your BMI under 25 OR to have you lose 10% of your body weight if your BMI is already greater than 27.5.
The study will enroll patients over a 5 year period. Each participant will be involved in the study for a minimum of 1 year and a maximum of 3 years. 3 years.
Sixty different medical centers in the United States are part of this study. All of these medical centers will report to the Clinical Coordinating Center, which is located at the Medical University of South Carolina, and the Statistical Coordinating Center at Emory University. 764 patients will be enrolled in the study nationwide.